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Mightex Systems, with operations based in Toronto, Canada, and in the Silicon Valley, California, is a leading supplier of photonic products and services for a broad spectrum of applications including industrial imaging, bio-photonic solutions, LED illumination, machine vision, life & health sciences, and industrial test & measurement etc.
OASIS Implant - Deep-Brain Imaging & Stimulation System for Freely Behaving Animals
- In vivo all-optical recording and manipulatiion of neural circuit activity;
- Sub-cellular resolution, high-quality imaging for quantitative analysis;
- Multi-wavelength illumination;
- Patterned stimulation with sub-cellular targeting capability;
- Super-light head mounted fixture, 0.3g;
- Modular system design, reconfigurable for different applications.
Mightex's OASIS Implant is a ground-breaking microendoscopic system that is capable of doing deep-brain simultaneous all-optical recording and manipulation of neural circuit activity with cellular resolution, on freely behaving animals. Compatible with high-sensitivity research-grade cameras, OASIS Implant enables researchers to acquire far superior quality deep-brain images & videos, compared to the relatively low-quality head-mounted cameras that have recently been introduced into the market. In addition, with multiple illumination ports, OASIS Implant is equipped with both wide-field and patterned illumination capabilities (when combined with Mightex's market-leading Polygon400) and, moreover, it is also capable of doing multi-wavelength imaging/stimulation which cannot be done with the existing head-mounted cameras. More importantly, since both the deep-brain imaging and the deep-brain stimulation are delivered through an Imaging Fiber bundle, the overall weight of the head-mounted fixture is as little as 0.3g (compared to approximately 2g with a head-mounted camera), making OASIS Implant an ideal research tool for in vivo live animal experiments.
In addition to many other applications, OASIS Implant enables bioscientists to do the following:
- Deep brain calcium imaging in freely behaving animals;
- Deep brain patterned optogenetic stimulation with single-cell or sub-cellular resolution;
- Simultaneous deep brain stimulation and imaging.
PhenoSys is a research- and development-oriented company based in Berlin, Germany. They engineer and market cutting edge technology for automated animal behaviour research. Their team draws on extensive expertise of electrical and mechanical engineering, computer science, and behavioural biology.
PhenoSys offers unique, automated instrumentation in the field of behaviour biology. This includes specialised applications of virtual reality and touch screen technology for animal behaviour environments and RFID (transponder) operated devices in home cage environments. Phenosys' experimental systems are used for behavioural phenotyping, brain research, experimental psychology, and the diagnostic characterisation of animal models for translational medicine.
Virtual Reality Systems enable rats and mice to enter a virtual reality world. These platforms offer a revolutionary concept for research on animal learning, memory, cognition, and navigation. They provide an environment of optimal control when investigating how animals process complex information. Furthermore, simple and complex behaviour can be explored in-depth.
Their VR platforms are highly flexible and modular solutions. Stimulation is not only visual but can be extended to 3D sound, odours and tactile information. It is easy to interface to existing hard- and software for in-vivo measurements or brain stimulation.
The Jet Ball is a novel virtual reality experimental system. It is based on an air supported spherical treadmill and allows a restrained animal to navigate in virtual space. Virtual reality provides an experimental environment with optimal control and can be used for investigating navigation, cognition, learning, and memory.
Restrained animals can be examined with electrophysiological and optogenetic methods while the animal performs simple or complex behaviour.
The Virtual Reality Servo Ball is a novel virtual reality experimental system. It is based on an active, servo driven spherical treadmill. It allows a video-tracked freely moving animal (e.g. mouse, rat) to navigate in virtual space. Virtual reality provides a perfectly controllable experimental environment. It can be used for investigating navigation, cognition, learning and memory.
A wide range of brain circuits can be stimulated through diverse operant protocols and multi-modal sensory stimulation. For unrestrained animals even 24-hour experimentation is possible.
Over the last decade touchscreen methods for rodents have become an efficient and powerful diagnostic method. Touchscreens are now widely used for cognitive testing and therapeutic screening of rodent models for translational research. They permit behavioural, lesion, and pharmacological studies.
Their touchscreen systems are integrated into Their automation technology platform. They have been designed to the highest degree of automation available in the industry. They allow the testing of tens of individuals at high-throughput rates with 24/7 automation without experimenter intervention. This minimizes human animal-handling and cuts on labour cost.
Individual Tracking with RFID-Technology
Mice and rats are highly social animals. Therefore, automated analysis of rodents living close together in their social group requires sophisticated methods. For tracking individuals within the home cage for 24/7, PhenoSys developed the innovative high resolution radio frequency identification technology. This powerful technology is capable of supporting social behaviour video analysis and in an additional application is even suitable for measuring locomotor activity of individuals.
The analysis of social behaviour in rodent models represents a powerful translational tool, particularly for studying psychiatric and neurological disorders. Social interactions of mice and rats are typically investigated by a human observer scoring behavior from video data. However, the identification of a single animal within groups of two or more uniform animals is difficult to perform.
The PhenoSys Social Video enhances video data by displaying RFID-based identification of individual animals in the video. Video-embedded symbols specific to each individual allow the human observer to easily follow individual animals throughout long videos.
Activity and movement is a fundamental diagnostic parameter of animal behaviour. However, measuring long-term individual movement within groups was not possible until now. Our Activity Monitor provides accurate individual movement data with full automation. It is a unique solution for the long-term tracking of individual animals living in groups.
The sensor plate placed underneath a cage detects individuals and tracks them as they move through the cage. Automated and long-term assessment of individual activity is made possible without having to place individuals in separate cages. The Activity Monitor utilizes RFID-technology.
Automated Group Cage (AGC)
The Automated Group Cage allows evaluation of sensory function, learning, cognition, and emotion while animals live stress-free in a social group in their home cage. It operates with high-throughput efficiency, significantly reducing lab resources.
The Automated Group Cage allows extensive behavioral diagnostics of neurological or psychiatric symptoms of brain function.
In multi-cage environments the selective passage of transponder-tagged animals or simply the registration of individual movement is possible with our ID-Sorter and ID-Tube.
It is beneficial for animals to live in groups rather than in single housing. Many behavioural diagnostic tests, however, require an individual animal to be alone while tested. Traditionally, this requires manually placing an animal from a home cage to the test arena and back. This process is fully automated with the ID-Sorter connecting the home cage to the test arena.
The ID-Sorter allows the selective passage of a single animal to the test arena and back. While in the operant chamber individual experiments can be conducted with independent experimental control software. Our system can be interfaced to operant systems from other vendors or to video observation systems.
The ID-Tube is an individual recognition sensor. It allows connecting two cages to multi-cage environments. It senses the direction of movement of any animal passing. It allows monitoring the formation of social sub-groups. It can be used to monitor spatial preferences.
The multi-channel olfactometer provides fast-response odour stimulation. It is a sophisticated tool for visualizing and quantifying activity in olfactory sensory neurons and the olfactory bulb for investigating olfactory quality coding. Our olfactometer systems allow perfect control of multiple stimuli and stimulus concentration.
The preparation of high quality odour mixtures is a complex process. With the automated olfactometer and its software this is made a standard laboratory routine that can be used and integrated easily for the behavioural assessment of odour-detection and for odour discrimination behaviour.
qOMR - quantitative optomotor response
The optomotor response (OMR) is a reflex used to assess visual function. To evoke OMR, a mouse watches a striped pattern rotating within a cylinder. Stimulus-correlated head movements are quantified to determine visual thresholds.
The PhenoSys qOMR (quantitative OMR) is a unique system that automatically measures the OMR with minimal experimenter effort. It uses a virtual stimulation cylinder that continuously aligns with the animal´s head position. Based on real-time head tracking, quantitative OMR measurements run fully automatically and objectively. This is a PhenoSys Collaboration product that is brought to market together with its developer, Dr. Friedrich Kretschmer.
- Simple, robust, and non-invasive test to examine vision in rodents
- Fully automated measurement and analysis: no manual positioning of the stimulus, no specially trained experimenter required, time and cost effective, and unbiased
- As a reflex, OMR measurements do not require animal training
- Freely behaving animals, no surgery, no fixation
- Flexible, user-friendly experimental design and data handling.