MBF Bioscience

MBF Bioscience Microbright field Spot

MBF Bioscience design quantitative imaging software for stereology, neuron reconstruction and image analysis, integrated with the world’s leading microscope systems to empower your research. Their development team and staff scientists are actively engaged with leading bioscience researchers, constantly working to refine their products.

Website: http://www.mbfbioscience.com

Stereo Investigator

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Stereo Investigator


Count cells and quantify lengths, areas, and volumes with the world's best and most-cited stereology system.

Stereology is considered in most biological sciences to be the most accurate and efficient way to estimate the number, length, and volume of cells.

A Stereo Investigator system for stereology gives you accurate, unbiased estimates of the number, length, area, and volume of cells or biological structures in a tissue specimen. It is a key research tool that has helped lead advances in numerous areas of neuroscience including neurodegenerative diseases, neuropathy, memory, and behavior, as well as other research fields including pulmonary research, spinal cord research, and toxicology.

Stereo Investigator has been cited in over 4,000 published research papers.

Unbiased stereology with Stereo Investigator - Overview


Extension Modules
  • Virtual Tissue 2D - Create 2D whole slide images
  • Virtual Tissue 3D - Create 3D whole slide images
  • Image Stack and 3D Visualization - Acquire and view 3D image stacks suitable for stereology
  • Image Montaging - Automated 3D montaging/stitching of image stacks
  • MRI Support - Analyze MRI image sets
  • Serial Section Reconstruction - 3D anatomical reconstructions from serial sections
  • Deconvolution - Deconvolution of brightfield, widefield fluorescence, and confocal images
  • Structured Illumination - Control of structured illumination hardware such as the Zeiss Apotome
  • Zen Control - Unbiased cell counting/stereology on a Zeiss LSM confocal microscope
  • Open Confocal - Unbiased cell counting/stereology on a confocal microscope
  • Fluoview - Unbiased cell counting/stereology on Olympus Fluoview 300 & 500
 

More information at MBF Bioscience's website: click here

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Neurolucida

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Neurolucida


An advanced system for neuron tracing and reconstruction, neuron analysis, and 3D brain mapping


Analyze the structure of neurons by tracing them in 3D with Neurolucida. Trace neurons at a microscope from a physical slide, or at a computer with image stacks. Obtain a wide variety of quantitative data about dendrites, axons, nodes, synapses, and spines.

Neurolucida is advanced scientific software for brain mapping, neuron reconstruction, anatomical mapping, and morphometry. Since its debut more than 20 years ago, Neurolucida has continued to evolve and has become the worldwide gold-standard for neuron reconstruction and 3D mapping. Researchers have reconstructed tens of thousands of neurons using our technology.

The user-friendly interface gives you rapid results, allowing you to acquire data and capture the full 3D extent of neurons and brain regions. You can reconstruct neurons or create 3D serial reconstructions directly from slides or acquired images, and Neurolucida offers full microscope control for brightfield, fluorescent, and confocal microscopes.

Neurolucida is available in two separate versions: Standard, which controls research microscope hardware and Workstation, for offline analysis away from the microscope. The software provides automatic analysis of hundreds of quantitative parameters, with results presented in graphical and spreadsheet format, all exportable to Microsoft Excel ®.

More information at MBF Bioscience's website: click here


Extension Modules
AutoNeuron

AutoNeuron traces neurons from image stacks or whole slides in minutes, significantly reducing time and effort. AutoNeuron works with brightfield, widefield fluorescence, and confocal images.

AutoNeuron

AutoSpine

AutoSpine is a ground-breaking tool for automatic detection and quantification of dendritic spines. Using high-quality dendritic tracings from AutoNeuron or Neurolucida, AutoSpine identifies and counts the spines along the traced dendrites.

AutoSpine

AutoSynapse

AutoSynapse, an extension module for Neurolucida, automatically detects and analyzes pre-synaptic markers such as synaptophysin and post-synaptic markers such as PSD95, then uses nearby dendrites traced with AutoNeuron or Neurolucida to analyze which of those synaptic markers are associated with particular dendrites.

AutoSynapse

Other Modules

AutoSynapse, an extension module for Neurolucida, automatically detects and analyzes pre-synaptic markers such as synaptophysin and post-synaptic markers such as PSD95, then uses nearby dendrites traced with AutoNeuron or Neurolucida to analyze which of those synaptic markers are associated with particular dendrites.

  • Virtual Tissue 3D for creating 3D whole slide images
  • Virtual Tissue 2D for creating 2D whole slide images
  • Image Montaging for automated 3D montaging/stitching of image stacks
  • Image Stack and 3D Visualization for acquiring and viewing 3D image stacks
  • Deconvolution for the deconvolution of brightfield, widefield fluorescence, and confocal images
  • Structured Illumination for integration with structured illumination microscopy hardware
  • Zen control for integration with Zeiss LSM confocal microscopes
  • Open confocal control for integration with confocal microscopes
  • Fluoview control for integration with Olympus Fluoview 300 & 500.
 

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Live Cell Imaging, Low Light Imaging

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Densita


Analyze autoradiography and optical density

Densita manages your autoradiography study with the most efficient workflow available.

First-time users can be productive with our intuitive technology, which includes specific steps for acquiring images, calibrating, linking total- and non-specific binding images, outlining regions, and exporting results to Microsoft Excel ®.

Using an optical step wedge or radioactivity standards, Densita quickly and efficiently calculates ROD (relative optical density), luminance, concentration, the area of your region of interest, ligand concentration, and the amount of radioactivity.

Densita can acquire new images, load previously-saved images, or read your existing MCID files. It also includes the ability to montage, and it supports multi-channel fluorescence images.

Another feature that sets Densita apart is its ability to automatically recalculate your results any time you adjust the data, at any point in the workflow. There is no need to recapture the image or start over from the beginning. Simply make the change, and Densita will re-do the work for you.

See what our complete autoradiography system can do for your lab.

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Live Cell Imaging, Low Light Imaging

MBF Bioscience Microbright field

Microlucida

For microscope control and image acquisition

Our newest product, Microlucida, builds on our core software framework of Neurolucida and Stereo Investigator, and provides all the tools necessary for advanced microscope control and image acquisition for brightfield, fluorescence, and confocal systems. It is the ideal application for research scientists who need to capture images in 2D, 3D, and 4D.

Microlucida gives you the power to acquire images from multiple fields of view and create seamless image montages, known as virtual slides. It also enables you to use a single high-quality image acquisition application across all of your microscopes, a feature particularly beneficial for core facilities.

Microlucida can save large amounts of disk space with its high-quality JPEG 2000 compression of images and stacks. Microlucida also enables time-lapse image acquisition over multiple channels.

With support for research microscopes from Zeiss, Olympus, Nikon, and Leica, Microlucida is also custom-designed for seamless integration with the world's leading motorized stages and cameras.

Capture images easily with Microlucida.