sCMOS - Scientific CMOS

Back illuminated sensor
Prime sCMOS cameras

Prime95B - 1.4MP Back Illuminated Scientific CMOS

Photometrics Prime 95B is the Scientific CMOS with extreme sensitivity using high Quantum Efficiency (QE) Backside Illumination (BSI), a first for Scientific CMOS cameras. The 95B’s sensor converts up to 95% of incident photons into a measurable signal. Unlike microlens approaches to increasing QE, which lose effectiveness as objective magnification is increased, Prime 95B’s BSI sensor brings light into the pixel photodiode from behind, avoiding structures that reflect or absorb light. When combined with large 11μm pixels, Prime 95B can deliver over 300% more signal than other sCMOS cameras at 100X magnification.

More importantly, Prime 95B outperforms EMCCD cameras—with no excess noise that negates the benefit of using a high QE sensor, and additional limitations from EM gain calibration, stability, expense, and sensor lifetime. With a true 16-bit dynamic range, Prime 95B easily accomplishes what EMCCD can not—detect weak and bright signals within the same image with photon-noise limited performance.

  • 95% Quantum Efficiency
  • 11μm x 11μm Pixel Area
  • 1.3e- Read Noise (median)
  • 41fps @ 16-bit / 82fps @ 12-bit

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Wiki: Back Illuminated Sensors

Front illuminated sensor
Prime sCMOS cameras

Prime sCMOS Camera

4.2 Megapixel Scientific CMOS Camera

Photometrics Prime is the first intelligent scientific CMOS (sCMOS) camera to incorporate a powerful FPGA-based Embedded Signal Processing™ engine (ESP). ESP enables advanced real-time processing features:

  • PrimeEnhance™ quantitatively increases the Signal to Noise Ratio by 3X-5X, increasing the clarity and quality of images.
  • PrimeLocate™ dynamically evaluates acquired images and reduces the surplus of data generated during high speed super resolution imaging.

Designed using sCMOS sensor technology, Prime becomes an extremely versatile life science imaging solution. It is a high resolution camera with great sensitivity, extremely low noise, high frame rates and impressive dynamic range. The large field of view is ideal for microscopy, maximizing usefulness of the imaging area.

Prime's embedded signal processing engine quantitatively restores images that are hidden in photon shot noise. Learn more its advanced, real-time processing features.

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Front illuminated sensor

PCO Edge

The pco.edge family of sCMOS cameras features an excellent combination of high resolution, high quantum efficiency, high frame rates and high dynamic range. All pco.edge cameras are available with various interface options.

pco.edge 3.1
  • 1.1 e- med readout noise
  • 2048 x 1536 pixel resolution
  • 27 000 : 1 dynamic range
  • rolling ∓ global shutter functionality
  • USB 3.0 interface
pco.edge 4.2
  • lowest readout noise of 0.8 e- med
  • high resolution of 2048 x 2048 pixel
  • dynamic range of 40 000 : 1 (USB) / 35 500: 1 (CL)
  • quantum efficiency up to 82%
pco.edge 5.5
  • extreme low readout noise of 1.1 e- med
  • high resolution of 2560 x 2160 pixel
  • dynamic range of 30 000 : 1
  • rolling & global shutter functionality
  • maximum frame rate 100 fps
pco.edge 4.2LT
  • 0.8 e- med readout noise
  • 2048 x 2048 pixel resolution
  • 37 500 : 1 dynamic range
  • >70% quantum efficiency
  • USB 3.0 interface
pco.edge CLHS
  • New interface for highest data throughput
  • up to 1.1 GB/s bandwidth
  • extensive FOL cable distance
  • 100 fps maximum frame rate
  • small form factor
  • pco.edge 4.2 & 5.5 compatible

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Front illuminated sensor

OptiMOS - 2.1MP sCMOS

The new sCMOS Camera and CCD alternative from QImaging

OptiMOS from QImaging is the live cell replacement to CCD cameras. Featuring faster frame rates and lower noise, optiMOS was designed as the budget friendly alternative that avoids complex data management in the PC. Capable of streaming 100fps with a 45% larger FOV and <2e- of read noise, optiMOS delivers 10x the time resolution of CCD cameras without trading off on resolution or sensitivity.


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