SLICE™ - Award-Winning Light-Sheet Microscopy Microscope
SLICE™ - a groundbreaking light-sheet microscopy system by MBF Bioscience, brings together high performance, remarkable affordability, and a compact benchtop footprint. Born in the Tomer Lab at Columbia University and built on Projected Light Sheet Microscopy (Chen et al., 2024), SLICE won the 2025 Microscopy Today Innovation Award and is now installed at more than 30 leading research institutions across three continents. SLICE™ opens the door to advanced 3D imaging for research labs of every size, delivering high-resolution imaging of biological samples for both individual laboratories and core facilities.
It SLICE™ images whole mouse brains, cleared organs, and organoids at sub-micron resolution. It handles every major clearing technique, including iDISCO, CLARITY, CUBIC, and BINAREE, without a single hardware change. It fits on a lab bench, needs no vibration isolation table, and is quiet enough to live in the room where your samples are prepared. And BrightSLICE — the complete acquisition, processing, and visualization software — comes with every system. No separate license. No third-party stack to assemble.
With its compact benchtop design, SLICE™ can be installed exactly where research happens, from higher biosafety environments and smaller laboratory spaces to even inside incubators, making SLICE™ a versatile platform for next-generation biological imaging.